Versatile Substrates and Probes for IgA1 Protease Activity.

Kritzer, Joshua A.

Choudary, Santosh K.

Qiu, Jiazhou.

Plaut, Andrew G.

2013.

Description
  • Bacterial meningitis is a severe infectious disease with high mortality. Gram-positive and Gram-negative bacteria that cause meningitis secrete immunoglobulin A1 (IgA1) proteases to assist in mucosal colonization, invasion, and immune evasion. IgA1 proteases have unique selectivity, with few reported substrates other than IgA1 from human tissue. Here we describe the design, characterization, and a... read more
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  • Choudary, S. K., Qiu, J., Plaut, A. G. and Kritzer, J. A. (2013), Versatile Substrates and Probes for IgA1 Protease Activity. ChemBioChem, 14: 2007-2012. doi:10.1002/cbic.201300281
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