Dynamic Model of Chinese Hamster Ovary Cell Metabolism in Fed-Batch Culture.

Nolan, Ryan.


  • Abstract: In this work, the design and execution of a mechanistic metabolic model is presented that is capable of simulating extracellular metabolite concentration profiles, particularly cell density and antibody titer, throughout the course of a recombinant protein producing CHO fed-batch culture. In Chapter 2, formulation of a reaction network is described wherein a genome scale metabolic ... read more
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