Inhibition of 2-methoxyestradiol glucuronidation by probenecid.

Qian, Yuli.


  • Abstract: 2-Methoxyestradiol (2ME2), a metabolite of estradiol, has antitumor activity in vitro. However, potential clinical applicability has been limited by its low oral bioavailability. Glucuronidation via UDP-glucuronyl transferases (UGTs) is the major metabolic pathway that is responsible for the low oral bioavailability of 2ME2. In the present study, probenecid was evaluated in vitro as an i... read more
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