Metabolic Syndrome, Helicobacter pylori, and cagA. The Association between the Disease, the Microbe, and the Gene.
Abu Dabrh, Abd Moain.
Background: Helicobacter pyloriand its virulent cagA gene have been linked to
cardiometabolic disease but the evidence is inconclusive. The aim of the study was to
assess the association between serostatus of H. pylori and cagA gene and prevalence of
metabolic syndrome. Methods: Data from the baseline visit of the Calcium and vitamin D
for Diabetes Mellitus (CaDDM) trial were used t... read moreo assess prevalent of metabolic syndrome
status based on the American Heart Association criteria. Other outcomes included the
Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and inflammatory and
vascular markers. Study participants were tested for H. pylori and cagA prevalence using
ELISA IgG serology tests. We assessed the association of metabolic syndrome and its
individual components with H. pylori and cagA sera status using chi-square and t-tests
and adjusted for potential confounding by age, gender, ethnicity, race, family history
of diabetes mellitus, and BMI. Results: One hundred ninety-seven participants were
eligible for this study. 59% were women, 76% were white and 94% were non-Hispanic or
non-Latino. Their average age was 60 years and their mean BMI was 32.1 kg/m².
Metabolic syndrome was present in 38% of participants with H. pylori and in 42% of those
without H, pylori (p= 0.36). Among those with H. pylori, metabolic syndrome was present
in 40% who had cagA gene and in 35% of those without cagA gene (p=0.70). Among metabolic
syndrome components, there was no associations with H. pylori or cagA except for waist
circumference which was associated with H. pylori (adj; p=0.04), and blood pressure
which was associated with cagA (adj: systolic; p=0.03, diastolic; p=0.05). Inetrleukin-6
was only associated with cagA (unadj: p=0.04), while VCAM and ICAM showed association
with H. pylori (unadj: ICAM; p=0.01, VCAM; p=0.03; adj: ICAM; p=0.05, VCAM; p=0.04).
Conclusion: In this study, H. pylori and cagA gene seropositivity was not associated
with metabolic syndrome. Associations between H. pylori and cagA seropositivity and
specific vascular and inflammatory markers need further investigation in different and
Thesis (M.S.)--Tufts University, 2012.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: ANASTASSIOS PITTAS.
Committee: HARRY SELKER, and CHRISTOPHER SCHMID.
Keyword: Medicine.read less