Finding NEMO: A bifurcated pathway of NF-B activation occurs via the recruitment of NEMO to polyubiquitin scaffolds at TCR

DeRiso, Elizabeth.

2017

Description
  • Abstract: Recent advancements in the field of cancer immunotherapy take advantage of T cell signaling controls, highlighting the importance of fully understanding basic signaling mechanisms for therapeutic targeted use. The NF-κB essential modulator protein (NEMO), also known as IKKγ, regulates canonical activation of the pro survival and growth transcription factor, NF-κB, downstream of the T... read more
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