| Description |
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Background: Reactive oxygen species (ROS), superoxide and hydrogen
peroxide (H2O2), are necessary for appropriate responses to immune challenges. In the
brain, excess superoxide production predicts neuronal cell loss, suggesting that
Parkinson's disease (PD) with its wholesale death of dopaminergic neurons in
substantia nigra pars compacta ... read more(nigra) may be a case in point. Although microglial
NADPH oxidase-produced superoxide contributes to dopaminergic neuron death in an MPTP
mouse model of PD, this is secondary to an initial die off of such neurons,
suggesting that the initial MPTP-induced death of neurons may be via activation of
NADPH oxidase in neurons themselves, thus providing an early therapeutic
target.
Keywords: 6-hydroxydopamine, angiotensin II type 1 receptor, adenosine
5'-triphosphate, cell determinant, cyclohexamide, dopamine transporter,
dichloro-fluorescein diacetate, human embryonic kidney, 1-methyl-4-phenylpyridinium,
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, nicotinamide adenine dinucleotide
phosphate, non-targeting control, phenylarsine oxide, Parkinson's disease, phagocytic
oxidase, reactive oxygen species, reverse transcriptase polymerase chain reaction,
tyrosine hydroxylase.
Springer Open.read less
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This object is in collection
| Citation |
- Zawada, W, Gregg P. Banninger, Jennifer Thornton, Beth
Marriott, David Cantu, Angela L. Rachubinski, Mita Das, W. Sue Griffin, and Susan M.
Jones. "Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+)
treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade."
Journal of Neuroinflammation 8, no. 1 (12, 2011): 1-13.
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