Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation.

Muchir, Antoine.

Kim, Young Jin.

Reilly, Sarah A.

Wu, Wei.

Choi, Jason C.

Worman, Howard J.

2013

Description
  • Background: Autosomal Emery-Dreifuss muscular dystrophy is caused by mutations in the lamin A/C gene (LMNA) encoding A-type nuclear lamins, intermediate filament proteins of the nuclear envelope. Classically, the disease manifests as scapulo-humeroperoneal muscle wasting and weakness, early joint contractures and dilated cardiomyopathy wi... read more
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  • Muchir, Antoine, Young Jin Kim, Sarah A. Reilly, Wei Wu, Jason C. Choi, and Howard J. Worman. "Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation." Skeletal Muscle 3, no. 1 (12, 2013): 1-10.
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