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Background: Vascular smooth muscle cell (VSMC) hyperplasia plays an
important role in both chronic and acute vascular pathologies including
atherosclerosis and restenosis. Considerable work has focused on the mechanisms
regulating VSMC proliferation and motility. Earlier work in our lab revealed a novel
growth arrest-specific (gas) gene ... read moreinduced in VSMC exposed to the antiproliferative
agent heparin. This gene is a member of the CCN family and has been given the name
CCN5. The objective of the present study is to elucidate the function of CCN5 protein
and to explore its mechanism of action in VSMC.
Keywords: Smooth muscle, proliferation, motility, CCN genefamily,
heparin, RNAi.
Springer Open.read less
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