GABA-A alpha-5 subunit manipulation of maternal separation-induced anxiety in mice

Sloley, Stephanie S.


  • Rodent models were used to examine the role of alpha-5 subunit containing GABAA receptors in modulating anxiety-like behavior through the maternal separation procedure, a reliable model for eliciting early life stress in rodents (Levine, 1957). In the brief separation procedure, subjects were separated from the dam and tested following subcutaneous injections of 0, 3, 5.6, 10, 17 or 30 mg/kg of th... read more
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