Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.

Kaplan, David, 1953-

Özkucur, Nurdan.

Quinn, Kyle P.

Pang, Jin C.

Du, Chuang.

Georgakoudi, Irene.

Miller, Eric L.

Levin, Michael.

2015

Description
  • Background: The disruption of neuron arrangement is associated with several pathologies. In contrast to action potentials, the role of resting potential (Vmem) in regulating connectivity remains unknown. Methods: Neuron assemblies were quantified when their Vmem was depolarized using ivermectin (Ivm), a drug that opens chloride channels, for 24 h in cocultures with astrocytes. Cell aggregation was... read more
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  • Özkucur, N., K. P. Quinn, J. C. Pang, C. Du, I. Georgakoudi, E. Miller, M. Levin and D. L. Kaplan (2015). "Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures." Brain and Behavior 5(1): 24-38. doi: 10.1002/brb3.295.
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