Design, Synthesis, and Characterization of Potent and Specific Inhibitors for Dipeptidyl Peptidase II.

Arciprete, Michael.


  • Abstract: This paper reports on a systemic screen for potent and selective dipeptidyl peptidase (DPP) II inhibitors. The boronic acid derivative boroNorvaline (boroNva) was designated as the P1 position amino acid and a library of amino acids, both natural and synthetic, were coupled with boroNva to form dipeptide inhibitors. The inhibitors were tested against the members of the DPPIV activity ... read more
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