Guarding the vacuole: how Legionella T4SS substrate SdhA maintains vacuole integrity.

Anand, Ila.


  • Legionella pneumophila is a Gram-negative, intracellular pathogen that targets amoebal species in aquatic environments and alveolar macrophages in humans. To sustain intracellular replication, L. pneumophila uses a type IV secretion system (T4SS) that translocates bacterial protein substrates into the host cytoplasm. These T4SS substrates are involved in the biogenesis of a membrane-bound ... read more
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