Performance of creatinine-based glomerular filtration rate estimating equations in solid-organ transplant recipients.
assessment of kidney function is of critical importance for the management of solid-
organ transplant recipients. In the general population, glomerular filtration rate (GFR)
is most commonly estimated using the Chronic Kidney Disease-Epidemiology (CKD-EPI)
equation and the Modification of Diet in Renal Disease (MDRD) Study equation. However,
the accuracy of these and other ... read moreGFR estimating equations in solid organ transplant
recipients has not been carefully studied and there has been some hesitation among
transplant physicians to use them. We performed a comprehensive review to identify all
published creatinine-based eGFR equations and compared their performance to the CKD-EPI
equation and the MDRD Study equation in a cohort of solid organ transplant recipients,
all of whom had GFR measured (mGFR) by a gold standard method. Performance was evaluated
using absolute bias (mean absolute error), P30202 BSA). The CKD-EPI equation was the
most accurate (P30301000 subjects or included race variable were more accurate than
those developed on smaller cohorts or did not included race. In solid organ transplant
recipients, the CKD-EPI and the MDRD Study equations perform as well as or better than
alternative equations. Since the CKD-EPI and the MDRD are the preferred equations in the
general population, practical reasons support their use in transplant
Thesis (M.S.)--Tufts University, 2013.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Andrew Levey.
Committee: Lesley Inker, Katrin Uhlig, Ronald Perrone, John Griffith, and Robin Ruthazer.
Keyword: Medicine.read less