Introduction: Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during pregnancy. However, extensive anatomical differences between mouse and human mammary tissues preclude the direct translation of rodent findings to the human bre... read moreast. Therefore, here we characterize the mammary progenitor cell hierarchy and identify the anatomic location of progenitor cells within human breast tissues.
Arendt, Lisa, Patricia J. Keller, Adam Skibinski, Kevin Goncalves, Stephen P. Naber, Rachel J. Buchsbaum, Hannah Gilmore, Steven E. Come, and Charlotte Kuperwasser. "Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules." Breast Cancer Research 16, no. 6 (10, 2014): 1-16.