Description |
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Background: The 4T1 mouse mammary tumor cell line is one of only a few
breast cancer models with the capacity to metastasize efficiently to sites affected
in human breast cancer. Here we describe two 4T1 cell lines modified to facilitate
analysis of tumor growth and metastasis and evaluation of gene function in vivo. New
information ... read moreregarding the involvement of innate and acquired immunity in metastasis
and other characteristics of the model relevant to its use in the study of late stage
breast cancer are reported.
Keywords: complementary RNA, Dulbecco's Minimum Essential Medium,
extracellular matrix, fetal bovine serum, flippase, FLP recombinase targeting site,
genetically engineered mouse, Ingenuity Pathway Analysis, myeloid derived suppressor
cells, normal calf serum, nonessential amino acids, phosphate buffered saline,
quantitative PCR, region of interest, small inhibitory RNA, short hairpin
RNA.
Springer Open.read less
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