Background: Recent increases in genomic studies of the developing human
fetus and neonate have led to a need for widespread characterization of the
functional roles of genes at different developmental stages. The Gene Ontology (GO),
a valuable and widely-used resource for characterizing gene function, offers perhaps
the most suitable func... read moretional annotation system for this purpose. However, due in part
to the difficulty of studying molecular genetic effects in humans, even the current
collection of comprehensive GO annotations for human genes and gene products often
lacks adequate developmental context for scientists wishing to study gene function in
the human fetus.
Keywords: Human development, Functional annotation, Databases, Gene
function, Fetal, Neonatal, Gene set analysis.
Wick, Heather, Harold Drabkin, Huy Ngu, Michael Sackman, Craig
Fournier, Jessica Haggett, Judith A. Blake, Diana W. Bianchi, and Donna K. Slonim.
"DFLAT: functional annotation for human development." BMC Bioinformatics 15, no. 1
(12, 2014): 1-10.