Background: The plasma lipoprotein response of F1B Golden-Syrian
hamsters fed diets high in very long chain (VLC) n-3 polyunsaturated fatty acids
(PUFA) is paradoxical to that observed in humans. This anomaly is attributed, in
part, to low lipoprotein lipase activity and is dependent on cholesterol status. To
further elucidate the mechanism(s) ... read morefor these responses, hamsters were fed diets
containing supplemental fish oil (VLC n-3 PUFA) or safflower oil (n-6 PUFA) (both 10%
[w/w]) and either cholesterol-supplemented (0.1% cholesterol [w/w]) or
cholesterol-depleted (0.01% cholesterol [w/w] and 10 days prior to killing fed 0.15%
lovastatin+2% cholestyramine [w/w]).
Lecker, Jaime, Nirupa R. Matthan, Jeffrey T. Billheimer,
Daniel J. Rader, and Alice H. Lichtenstein. "Changes in cholesterol homeostasis
modify the response of F1B hamsters to dietary very long chain n-3 and n-6
polyunsaturated fatty acids." Lipids in Health and Disease 10, no. 1 (12, 2011):
1-10.