Genetic Characterization of ABL1 Inhibition and Regulation by the Tumor Suppressor PRDX1.

Salazar, Marcos.

2012

Description
  • Abstract: The first portion of this thesis serves to further characterize the roles of PRDX1, mainly focusing on ABL1 regulation and oxidative stress. Our laboratory first discovered PRDX1 physically binds to c-ABL1 and suppresses its kinase activity. However, the interaction is not well defined. We found imatinib-resistant ABL1 kinase mutations, which are commonly seen in BCR-ABL1 of CML patients... read more
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