A highly synchronous murine model for EHEC infection reveals Shiga toxin promotes pathogen spread and systemic disease

Flowers, Laurice.

2017

Description
  • Abstract: Enterohemorrhagic Escherichia coli (EHEC) produces Shiga toxin, a phage-encoded toxin that is essential for triggering life-threatening hemolytic uremic syndrome and renal failure. How Stx targets the kidney and other extraintestinal tissues is poorly understood. EHEC does not efficiently colonized conventional mice, but gavage of mice with the related mouse pathogen, CR(stx), can cause ... read more
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