Investigating the Effects of Transcription and RNA Processing on CAG Repeat Fragility.

Fair, Stacey A.

2017-04-21

Description
  • CAG repeat sequences are found throughout the human genome and are hotspots of mutation due to their tendency to form non-B secondary structures. My work investigates the mechanisms behind the elevated CAG repeat fragility phenotypes of two RNA processing mutants: thp2∆ and trf4∆. While previous literature suggests that R-loops are the cause of genomic instability associated with these mutants, my... read more
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