Targeting a "hot loop" in the oncogenic Skp2-Cks1 protein-protein interaction with cyclic peptide inhibitors.

Keenan, Caitlin M.

2015

Description
  • This project involves the development of conformationally constrained mimetic peptides, informed by the Loop Finder program developed by the Kritzer Lab, to block the interaction between two subunits of a ubiquitin ligase. This protein-protein interaction is involved in regulating progression from G1 to S phase of the cell cycle and is associated with many types of cancer. Submitted in partial fu... read more
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