Preclinical evaluation of the NF-B pathway and -catenin as therapeutic targets in BCR-ABL1-induced leukemia.

Hsieh, Mo-Ying.


  • Abstract: The BCR-ABL1 oncoprotein, resulting from t(9;22) Philadelphia chromosome translocation, is the direct cause of chronic myeloid leukemia (CML) and is also found in some acute B-lymphoblastic leukemia (Ph+ B-ALL) patients. While allogenic stem cell transplantation can cure Ph+ leukemias, this procedure is risky, costly, and associated with graft-versus-host-disease. The standard initial ... read more
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