Comprehensive analysis of loops at protein-protein interfaces for macrocycle design.

Kritzer, Joshua A.

Gavenonis, Jason.

Sheneman, Bradley.

Siegert, Timothy.

Eshelman, Matthew R.

2014.

Description
  • Inhibiting protein-protein interactions (PPIs) with synthetic molecules remains a frontier of chemical biology. Many PPIs have been successfully targeted by mimicking -helices at interfaces, but most PPIs are mediated by non-helical, non-strand peptide loops. We sought to comprehensively identify and analyze these loop-mediated PPIs by writing and implementing LoopFinder, a customizable program t... read more
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  • Kritzer, J.A., Gavenonis, J., Sheneman, B., Siegert, T., Eshelman, M.R. Comprehensive analysis of loops at protein-protein interfaces for macrocycle design. Nat. Chem. Biol. 2014 10(9), 716-722. doi:10.1038/nchembio.1580.
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jm2151163
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