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Peptides and small, well-folded proteins are important and useful classes of molecules for drug development. Structured peptides and small protein scaffolds can be used to recapitulate natural 3D binding epitopes in a number of ways, including the application of covalent “staples” and by grafting epitopes onto a suitable scaffold protein. These methods, among others, require a known 3D binding ... read moreepitope as a starting point. This work discusses the identification of those epitopes, snd their use in grafting applications.read less
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