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In this project I explored two different methods for utilizing genetically modified tobacco mosaic viruses (TMVs) to robustly create tunable and functional nano-scale surfaces and structures. As highly stable nano-scale rods, TMVs provide for excellent nanotemplates that are programmable via nucleic acid hybridization and functionalizable with genetically inserted thiol groups in cysteine residues. ... read moreUtilizing gold-thiol binding and functionalization with fluorescein, fluorescence and atomic force microscopy (AFM) results clearly demonstrate the capacity for TMVs to specifically and tunably self-assemble onto gold surfaces while retaining thiol functionality. Utilizing the hybridization-based assembly of TMVs to DNA miniarrays, AFM results should also clearly demonstrate the capacity for TMVs to be selectively linked to form TMV dimers, trimers, and other arbitrarily complex geometries, although no conclusive results were obtained prior to the submission of this document. Either of these two methods might find applications in producing better catalysts, providing more functionality to sensing surfaces, or lending strength or functionality to nano-scale devices.read less
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