The Role of the S-phase DNA Damage Checkpoint in the Relocalization of CAG Trinucleotide Repeats to the Nuclear Pore Complex

Johnson, Matthew J.

2020

Description
  • The instability of CAG trinucleotide repeats has been known to cause neurodegenerative diseases including Huntington’s Disease and myotonic muscular dystrophy. Moreover, CAG trinucleotide repeats are capable of forming lesion inducing hairpin structures during the replication of DNA during S-phase. These lesions must be repaired in order for DNA to be faithfully replicated and properly segregated ... read more
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