A COMPARISON BETWEEN A TRIPLE ANTIBIOTIC MIX CONSISTING OF METRONIDAZOLE, CIPROFLOXACIN AND MINOCYCLINE, AND CALCIUM HYDROXIDE IN ROOT CANAL DISINFECTION OVER A PERIOD OF ONE WEEK.
Alyahya, Asma.
2011
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Abstract: Background: The elimination of microbial contamination of the root canal system is the key to successful root canal treatment. The purpose of the present study was to compare the disinfecting capacity of a triple antibiotic mix consisting of metronidazole, ciprofloxacin and minocycline to Ca(OH)2 over a period of one week. The alternative hypothesis of the superiority of the triple ... read moreantibiotic paste to Ca(OH)2 in disinfecting root canals when used as an intra-canal medicament for one week period was tested in this study. Methods: This was an in vitro, interventional study where extracted sound single- rooted mandibular premolars with closed apices were artificially infected with E. Faecalis. Infected samples were checked for baseline colony forming unit counts (CFUi). The sample roots were then randomly assigned to one of three groups: an experimental group received the triple antibiotic mix, a positive control group received Ca(OH)2, and a negative control group received no intra-canal medicament. At the end of the experiment, roots were checked for final colony forming unit counts (CFUf). Results: Thirty extracted sound single-rooted mandibular premolars with closed apices were collected. The mean percent reduction in CFU count for triple antibiotic group was 100 %. The mean percent reduction in CFU count for Ca(OH)2 group was 99.99 %. The mean percent reduction in CFU count for negative control group was 93.4 %. Kruskal-Wallis test showed a statistically significant difference in the mean percentage reduction between the groups (Chi-square =25.85, p <0.0001). Post-hoc tests using Mann-Whitney U (p-value cutoff = 0.0167) showed statistically significant difference between Ca(OH)2 and triple antibiotic paste (p < 0.0001), between triple antibiotic paste and negative control (p < 0.0001) and between Ca(OH)2 and negative control group (p < 0.0001). Conclusions: Under the conditions of the present study, the disinfecting capacity of the triple antibiotic paste consisting of metronidazole, ciprofloxacin and minocycline was found to be superior to Ca(OH)2 when used as an intra-canal medicament over a period of one week.
Thesis (M.S.)--Tufts University, 2011.
Submitted to the Dept. of Other.
Advisor: Shiow-Jiin Jaw.
Committee: Cheen Y Loo, Driss Zoukhri, and Matthew Finkelman.
Keywords: Dentistry, and Microbiology.read less - ID:
- j3860k084
- Component ID:
- tufts:20236
- To Cite:
- TARC Citation Guide EndNote
