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Abstract: In
autoimmune disease patients, immune system intensifies the production of autoantibodies,
including Antinuclear antibodies (ANAs). Some patients with an elevated level of ANAs
take immunosuppressive drugs and receive hemodialysis to remove excess fluid, waste
substances, and ANAs. However, the current problem in hemodialysis is that it
excessively removes necessary proteins and ... read moreantibodies. This study describes a new
technique to engineer polymer beads to capture ANAs in the patient blood. The beads are
conjugated with HEp-2 cell nuclear proteins in which ANAs have binding specificity to.
This new technique allows autoantibodies to be 'fished-out' during the dialysis process,
providing an effective therapy for patients. The result showed that the microbeads can
significantly capture ANAs in ANA positive human serum. The microbeads captured 29.2
µg of ANAs per cm2 surface area of the beads. Application of the beads in dialysis
makes dialysis process to be a cost and time efficient
therapy.
Thesis (M.S.)--Tufts University,
2017.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Qiaobing
Xu.
Committee: Xiaocheng Jiang, and James Van
Deventer.
Keyword: Biomedical
engineering.read less
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