| Description |
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Abstract: Current evidence supports the notion that environmental
exposures are associated with DNA-methylation and expression changes that can impact
human health. Our objective was to conduct a systematic review of epidemiologic
studies evaluating the association between environmental chemicals with DNA
methylation levels in adults. ... read moreAfter excluding arsenic, recently evaluated in a
systematic review, we identified a total of 17 articles (6 on cadmium, 4 on lead, 2
on mercury, 1 on nickel, 1 on antimony, 1 on tungsten, 5 on persistent organic
pollutants and perfluorinated compounds, 1 on bisphenol A, and 3 on polycyclic
aromatic hydrocarbons). The selected articles reported quantitative methods to
determine DNA methylation including immunocolorimetric assays for total content of
genomic DNA methylation, and microarray technologies, methylation-specific
quantitative PCR, Luminometric Methylation Assay (LUMA), and bisulfite pyrosequencing
for DNA methylation content of genomic sites such as gene promoters, LINE-1, Alu
elements, and others. Considering consistency, temporality, strength, dose-response
relationship, and biological plausibility, we concluded that the current evidence is
not sufficient to provide inference because differences across studies and limited
samples sizes make it difficult to compare across studies and to evaluate sources of
heterogeneity. Important questions for future research include the need for larger
and longitudinal studies, the validation of findings, and the systematic evaluation
of the dose-response relationships. Future studies should also consider the
evaluation of epigenetic marks recently in the research spotlight such as DNA
hydroxymethylation and the role of underlying genetic variants.
Keywords: Systematic review, DNA methylation, Environmental chemicals,
Cadmium, Lead, Mercury, Metals, Persistent organic pollutants, Bisphenol A,
Polycyclic aromatic hydrocarbons.
Springer Open.read less
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| Citation |
- Ruiz-Hernandez, Adrian, Chin-Chi Kuo, Pilar Rentero-Garrido,
Wan-Yee Tang, Josep Redon, Jose M. Ordovas, Ana Navas-Acien, and Maria Tellez-Plaza.
"Environmental chemicals and DNA methylation in adults: a systematic review of the
epidemiologic evidence." Clinical Epigenetics 7, no. 1 (12, 2015):
1-24.
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