Background: The glaucomas are a common but incompletely understood group
of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately
causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously
that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However,
mechanisms involved ... read morein the subsequent IOP elevation and optic nerve degeneration
remain unclear.
Howell, Gareth, Richard T. Libby, Jeffrey K. Marchant,
Lawriston A. Wilson, Ioan M. Cosma, Richard S. Smith, Michael G. Anderson, and Simon
WM John. "Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of
Gpnmb and Tyrp1." BMC Genetics 8, no. 1 (12, 2007): 1-10.