The Role of Innate Immunity in Orchestrating Th17 Cell Pathogenesis in Severe Schistosomiasis.

Ponichtera, Holly.


  • Abstract: In murine Schistosoma mansoni infection, the magnitude of immunopathology and proinflammatory cytokine production in response to live schistosome eggs is strain dependent. Whereas infected CBA mice develop severe disease characterized by hepatic egg-induced granulomatous inflammation that is associated with prominent Th17 and Th1 cytokine responses, milder lesions develop in the Th2-pola... read more
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