Regulation of cartilage cell fate determination and homeostasis.

Cairns, Dana.


  • Abstract: We first studied the role of Shh in patterning the somite during early embryonic development. We found that differing levels of Shh signaling elicit differing responses from somitic cells: the lowest level of Shh signaling allows dermomyotomal gene expression, intermediate levels induce loss of dermomyotomal markers and activation of myogenic differentiation, and higher levels induce los... read more
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