Engineering a Biochemical Gradient in a 3D Small Intestinal Model with Topographical Features

Gee, Michelle M.


  • The small intestine has microscale crypt and villus structures that create functional niches for proliferative cells in the crypts and differentiated cells on the villi. The localization of these cells is driven by a biochemical concentration gradient of factors. However, current in vitro intestinal models have been unable to combine this crypt and villus architecture with a biochemical gradient ... read more
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