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Many studies have been
published indicating that the complex ecosystem that is the gut microbiota plays an
important role in human health, including in obesity risk, inflammation, and antioxidant
production. However, the gut species makeup varies greatly among individuals, and not
everyone receives that same benefits. Therefore, it is important to identify not only
what metabolites are providing ... read morethese beneficial effects, but also which organisms
produce them. Flavonoids, a class of polyphenolic compounds found in high abundance in
many plant sources, have gained attention recently for exhibiting anti-inflammatory,
antioxidant, and anti-cancer properties. In this study, we computationally predicted
metabolic derivatives of flavonoids from an expanded spinach model based on a mouse
cecal microbiota model. A selection of these predicted flavonoid derivatives were tested
for anti-inflammatory properties on HT29-MTX cells. Results were found to be
contradictory to previously published data. Predicted derivatives were found to have a
pro-inflammatory effect on HT29-MTX cells. Further studies need to be conducted to
confirm that these results are not exclusive to HT29-MTX
cells.
Thesis (M.S.)--Tufts University,
2019.
Submitted to the Dept. of Chemical and
Biological Engineering.
Advisor: Kyongbum
Lee.
Committee: Soha Hassoun, and Emmanuel
Tzanakakis.
Keyword:
Bioengineering.read less
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