Iterative, rational design of cyclic and bicyclic peptide inhibitors of matrix metalloproteinases 9 and 2

Davis, Matthew R.


  • Matrix Metalloproteinases are zinc metalloproteinases involved in cancer progression as well as acute inflammation. Gelatinase A and B, or MMP-2 and MMP-9, are members of this family implicated in extracellular matrix remodeling and angiogenesis. The disulfide-bridged decapeptide CTT is a potent inhibitor of Gelatinases, and has been shown to selectively target tumor cells. This work focused on ... read more
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