Small molecule inhibitors of NOD2 signaling targeting the receptor-interacting protein kinase 2

Dai, Bing.

2018

Description
  • Abstract: Receptor-interacting protein kinase 2 (RIPK2) mediates inflammatory signaling by the bacteria-sensing receptors Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1 and NOD2). Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD-mediated pathologies. Such as Crohn's diseases, Sarcoidosis, and inflammatory arthritis. For the further investi... read more
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