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Abstract: There are
currently limited models available for effectively studying lung diseases and drug
response aside from animal and clinical trials. This is due to the complexity of the
lung's structure and function. The goal of this project was to develop a proof of
concept three-dimensional tissue model of a lung alveolus capable of replicating the
ventilation cycle using a silk-based ... read morehydrogel. This hydrogel provides a scaffold to
incorporate a wider range of lung tissue components, including proteins and cells, as
compared to current cell culture models. The material properties of the hydrogel were
examined under physiologically accurate conditions for comparison to the native tissue.
With additional modification, this system shows promise of providing researchers with an
in vitro model that more closely replicates the complexities of the lung as compared to
current research options.
Thesis (M.S.)--Tufts
University, 2017.
Submitted to the Dept. of
Mechanical Engineering.
Advisor: David
Kaplan.
Committee: Gary Leisk, and Lauren Black
III.
Keyword: Biomedical
engineering.read less
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