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Abstract: There are currently limited models available for effectively studying lung diseases and drug response aside from animal and clinical trials. This is due to the complexity of the lung's structure and function. The goal of this project was to develop a proof of concept three-dimensional tissue model of a lung alveolus capable of replicating the ventilation cycle using a silk-based hydrogel... read more. This hydrogel provides a scaffold to incorporate a wider range of lung tissue components, including proteins and cells, as compared to current cell culture models. The material properties of the hydrogel were examined under physiologically accurate conditions for comparison to the native tissue. With additional modification, this system shows promise of providing researchers with an in vitro model that more closely replicates the complexities of the lung as compared to current research options.
Thesis (M.S.)--Tufts University, 2017.
Submitted to the Dept. of Mechanical Engineering.
Advisor: David Kaplan.
Committee: Gary Leisk, and Lauren Black III.
Keyword: Biomedical engineering.read less
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