The Advantage of Instability in Maintaining Function Within the Repetitive CTD of RNA Polymerase II

Exner, Alexandra.


  • Abstract: The carboxyl-terminal domain (CTD) of RNA polymerase II is composed of a tandemly repeating 7 amino acid sequence that is conserved amongst eukaryotes. The DNA that encodes repetitive amino acid sequences is thought to be unstable and prone to both expansion and contraction of the DNA sequence, resulting in protein products of different lengths. Previous studies have shown mutations that ... read more
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