Observations and insights from a study of RalGDS in cancer.

Wong, Richard.


  • Abstract: Ral exchange factors are transducers of Ras activation. These exchange factors target the small GTPases RalA and RalB. Four RalGEFs (RalGDS, Rgl 1, Rgl2/Rlf, and Rgl3) have been identified with the ability to bind Ras through a conserved Ras binding domain. Other Ral exchange (RalGPS1, RalGPS2, and Rgr) factors have also been identified which do not have RBDs and are thought to be ... read more
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