%0 PDF %T Neuro-inflammation, blood-brain barrier, seizures and autism. %A Theoharides, Theoharis C.; Zhang, Bodi. %D 2016-08-16T18:23:16.661Z %8 2016-08-16 %R http://localhost/files/gh93h977x %X Abstract: Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.; Keywords: Autism, Blood-Brain Barrier, Mast cells, Neuroinflammation, Flavonoids.; Springer Open. %[ 2018-10-11 %9 Text %~ Tufts Digital Library %W Institution