Background: A substrate cycle is a set of metabolic reactions, arranged
in a loop, which does not result in net consumption or production of the metabolites.
The cycle operates by transforming a cofactor, e.g. oxidizing a reducing equivalent.
Substrate cycles have been found experimentally in many parts of metabolism; however,
their physi... read moreological roles remain unclear. As genome-scale metabolic models become
increasingly available, there is now the opportunity to comprehensively catalogue
substrate cycles, and gain additional insight into this potentially important motif
of metabolic networks.
Sridharan, Gautham, Ehsan Ullah, Soha Hassoun, and Kyongbum
Lee. "Discovery of substrate cycles in large scale metabolic networks using
hierarchical modularity." BMC Systems Biology 9, no. 1 (12, 2015):