Fragility and Genomic Rearrangements at CTG Repeats

Del Priore, Isabella

2019

Description
  • Repetitive sequences, such as trinucleotide repeats, are fairly common throughout the eukaryotic genome and can contribute to several genetic diseases. Repeats can form secondary structures that interfere with cellular processes, such as replication and repair, making them prone to instability (expansions) and fragility (breakage). While there are multiple mechanisms to effectively repair breaks ... read more
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