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Background: Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in the optic nerve head during ocular hypertensive injury. We previously demonstrated that monocyte-like cells enter the optic nerve head in an ocular hypertensive mouse model of ... read moreglaucoma (DBA/2 J), but their roles, if any, in mediating axon damage remain unclear.
Keywords: Glaucoma, Retinal ganglion cell, Optic nerve, Monocyte, Vascular leakage, Extravasation, Platelet, Neuroinflammation, RNA-sequencing.
Springer Open.read less
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