A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake.

Kritzer, Joshua A.

Quartararo, Justin.

Eshelman, Matthew R.

Peraro, Leila.

Yu, Hongtao.

Baleja, James D.

Lin, Yu-Shan.

2014.

Description
  • While peptides are promising as probes and therapeutics, targeting intracellular proteins will require greater understanding of highly structured, cell-internalized scaffolds. We recently reported BC1, an 11-residue bicyclic peptide that inhibits the Src homology 2 (SH2) domain of growth factor receptor-bound protein 2 (Grb2) In this work, we describe the unique structural and cell uptake properti... read more
This object is in collection Subject Permanent URL Citation
  • Quartararo, J., Eshelman, M., Peraro, L., Yu, H., Baleja, J.D., Lin, Y., Kritzer, J.A. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg. Med. Chem. 2014 22(22), 6387-6391. doi:10.1038/nchembio.407.
ID:
g732dn57p
To Cite:
DCA Citation Guide    EndNote
Usage:
Detailed Rights