Background: MicroRNAs play important roles in regulating biological
processes, including organ morphogenesis and maturation. However, little is known
about specific pathways regulated by miRNA during lung development. Between the
canalicular and saccular stages of the developing lung several important cellular
events occur, including the ... read moreonset of surfactant synthesis, microvascular remodeling
and structural preparation for subsequent alveolarization. The miRNAs that are
actively regulated, and the identity of their targets during this important
developmental interval in the lung remain elusive.