A Novel Way to Study Human Hereditary Diseases: Modeling Large-Scale (CAG) Expansions in Yeast.

Harris, Samantha T.


  • Abstract: Approximately 30 human hereditary diseases have been linked to large-scale expansions of repetitive microsatellites, such as the (CAG)n trinucleotide repeat. Discovering how these repeats are expanding is central to the understanding of the disease progression in human pedigrees. While previous work with (GAA)n repeats has shed light on how these large-scale expansions are occurring, thi... read more
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