Synthesis of a Ganglioside GM1 Anchor for Membrane Tethered Ligands of G-Protein Coupled Receptors.

Sidhom, Eriene-Heidi.


  • G-protein coupled receptors, as a class of proteins, are most important therapeutically. It is estimated that over 50% of prescription drugs target these receptors.1 At nearly 1000 proteins, this family is divided into 5 classes, or families. The largest of these is Class A, the Rhodopsin family. This class is identifiable by conserved sequences which are critical for membrane activation. Among ... read more
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