| Description |
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Background: Autophagy is a major cellular process by which cytoplasmic
components such as damaged organelles and misfolded proteins are recycled. Although
low levels of autophagy occur in cells under basal conditions, certain cellular
stresses including nutrient depletion, DNA damage, and oxidative stress are known to
robustly induce ... read moreautophagy. Krüppel-like factor 4 (KLF4) is a zinc-finger
transcription factor activated during oxidative stress to maintain genomic stability.
Both autophagy and KLF4 play important roles in response to stress and function in
tumor suppression.
Keywords: Krüppel-like Factor 4, Autophagy, Apoptosis, Mammalian target
of rapamycin, DNA damage, Mouse embryonic fibroblasts, Autophagy related
genes.
Springer Open.read less
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This object is in collection
| Citation |
- Liu, Changchang, Elise P. DeRoo, Catherine Stecyk, Margaret
Wolsey, Mateusz Szuchnicki, and Engda G. Hagos. "Impaired autophagy in mouse
embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and
increases apoptosis upon serum starvation." Molecular Cancer 14, no. 1 (12, 2015):
1-13.
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