Investigating cis and trans factors involved in common fragile site breakage and healing using Flex1, a subregion of FRA16D

Kaushal, Simran.


  • Abstract: Common Fragile Sites (CFSs) are regions of DNA that display gaps and breaks in metaphase chromosomes under replication stress. While CFSs are not normally expressed, or broken, in individuals, conditions of replication stress result in their breakage. Evidence of such sites has been found in organisms ranging from yeast to humans. Further, CFSs are often sites of rearrangement in cancer ... read more
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