Deciphering the Domain-Specific Functions of Polymerase Theta During Interstrand Crosslink Repair in Drosophila Melanogaster.

Armstrong, Robin L.


  • Abstract: DNA polymerase θ (Pol θ) is upregulated in many human cancers which is associated with a poor prognosis for these cancer patients. The D. melanogaster homologue of Pol θ is encoded by mus308 and contains two domains, an N-terminal helicase-like domain and a C-terminal polymerase domain, connected by a central, non-conserved linker region. Unlike human Pol θ mutants, which are extremely r... read more
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